(cost)effectiveness of rTMS

Why this study?

In the DETECT project we study the effect of magnetic brain stimulation (rTMS) on depressive symptoms, in comparison with the usual treatment consisting of antidepressant medication. Patients will be treated with rTMS or with medication for a period of 8 weeks. During both treatments patients will also receive cognitive behavioral therapy (CBT). Subsequently, we examine the effect of both treatments on depressive symptoms, but also on quality of life. Furthermore, we compare the costs of the treatment options. This way we aim to determine which treatment is more (cost)effective.

After the treatment period of 8 weeks, the patients that have not yet received rTMS will be given  the chance to receive treatment with rTMS.

Where is this study carried out?

This study is carried out in four locations:

–  Radboudumc in Nijmegen

–  NeuroCare in Nijmegen, Eindhoven and Den Haag

–  ProPersona in Nijmegen and Arnhem

–  Elisbeth TweeSteden hospital in Tilburg

Who are we looking for?

You can participate in the study if you:

–  Have a unipolar depression

–  Have been treated unsuccessfully with antidepressant medication and/or psychotherapy twice

–  Have not been treated before with rTMS or ECT

What happens when you participate?

If you want to participate in this study, a researcher will first contact you by phone to tell more about the study and to answer any questions you might have. The researcher will also briefly check whether it is possible for you to participate. If you still want to participate after this conversation, you will be invited for an intake meeting.


During this meeting a psychiatrist will assess the severity of your symptoms. A researcher or research assistant will go through a few questionnaires with you. Finally, you will be asked to fill in some questionnaires online. In total this meeting shall take about 2 hours.

All participants in the study will be randomly allocated to either the rTMS group, or the medication group. The chance to be allocated to each group is about 50%. After the 8 week treatment period, the participants in the medication group will be given the chance the be treated with rTMS as well.


4, 6, 9 and 12 months after the start of the treatment, we will contact you again to see how you are doing and to fill in a questionnaire. We also ask you to fill in online questionnaires, both during and after the treatment.


Radboud UMC

Afdeling Psychiatrie

route 975a, Huispostnummer 966

Reinier Postlaan 10 

6525 GC Nijmegen

Iris Dalhuisen uitvoerend onderzoeker

T 06-50098382

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Radboud UMC

Department of Psychiatry

route 975a, House number 966

Reinier Postlaan 10

6525 GC Nijmegen

Iris Dalhuisen researcher

T 06-50098382